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The Effect of Hypophysectomy on the Experimental Production of Rat Thyroid Neoplasms¹

Department of Anatomy, McGill University, Montreal, Quebec, Canada

Hypophysectomized, sham-hypophysectomized, and nonoperated rats were injected with 3 µCi ¹³¹I or not injected and then placed on a low-iodine diet with or without iodine supplement. In 6 months, when follicular cell neoplasms (not necessarily light cell neoplasms) were expected to appear, the thyroid glands were examined under the light microscope and neoplasms were counted and measured by a histometric technique. The incidence of animals with follicular cell neoplasms in the sham-hypophysectomized group given 3 µCi ¹³¹I and the low-iodine diet was 96%, with a mean neoplasm number of 5.5/animal thyroid gland and a mean aggregate neoplasm volume of 0.57 x 10⁸ cu µ/animal thyroid gland. Sham-hypophysectomized animals given ¹³¹I alone did not develop neoplasms; hypophysectomized animals given a low-iodine diet alone, ¹³¹I alone, or a combination of both, also did not develop thyroid neoplasms. It is concluded that, in the rat, in the absence of thyroid-stimulating hormone stimulation, thyroid follicular cell neoplasms do not appear following an injection of 3 µCi ¹³¹I and/or a low-iodine diet.

¹ This work was supported by a grant of the National Cancer Institute of Canada.

Received 11/18/69. Accepted 2/ 4/70.

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