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RNA and Amine Synthesis in the Liver of Rats Given Injections of Thioacetamide¹

Division of Biological and Medical Sciences, Brown University, Providence, Rhode Island 02912

Nuclear RNA metabolism and amine synthesis were investigated in the liver of rats given injections of thioacetamide. A single injection of the drug causes a sharp increase in ornithine decarboxylase activity and a stimulation of the labeling of nuclear RNA. Puromycin and actinomycin D injections inhibit ornithine decarboxylase activity in thioacetamide-treated rats. Repeated injections of thioacetamide cause (a) accumulation of RNA in the nucleus, (b) increase in the amount of spermidine, and (c) a small decrease in spermine. The results suggest that there are parallel changes in RNA and amine metabolism under experimental conditions leading to increases in liver RNA synthesis and organ hypertrophy.

¹ This research was supported by Grant E-516 from the American Cancer Society.

Received 12/ 1/69. Accepted 3/ 6/70.