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Observations with a Variant of Lymphocytic Choriomeningitis Virus in Mouse Tumors¹

Lawrence Radiation Laboratory, University of California, Livermore, California 94550

A viscerotropic variant of lymphocytic choriomeningitis has been identified in an Ehrlich ascites tumor. This is apparently a unique variant of lymphocytic choriomeningitis virus. It does not cause death when injected intracranially into weanling mice; however, it does provide protection against a subsequent intracranial challenge with virulent lymphocytic choriomeningitis (CA 1371). The virus grows readily in vivo in two other lines of Ehrlich ascites tumor in outbred Swiss mice, as well as in Sarcoma I in A/Bi strain mice. The murine tumors, once infected with the virus, became less virulent and more susceptible to chemotherapy than their noninfected counterparts. In addition, it has been observed that cell-free fluids prepared from virus-infected tumors contain antigens which provide a tumor rejection immunity when used as a vaccine. A tumor treatment model consisting of in vivo virus infection with the viscerotropic lymphocytic choriomeningitis virus followed by chemotherapy has been tested and found effective for Ehrlich ascites tumors.

¹ Work performed under the auspices of the United States Atomic Energy Commission.

Received 10/17/69. Accepted 3/ 6/70.