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Dimethyl Sulfoxide, a Convenient Solvent of 7,12-Dimethylbenz(a)anthracene for Intravenous Injection¹

Institut de Médecine et de Chirurgie expérimentales, Université de Montreal, Montréal, Canada

Dimethyl sulfoxide is a convenient solvent of 7,12-dimethylbenz(a)anthracene and related polycyclic aromatic hydrocarbons for i.v. injection. As judged by its ability to induce both adrenal necrosis and mammary tumors, this solution is at least as active as fatty emulsions of 7,12-dimethylbenz(a)anthracene now in general use. While the preparation of emulsions is time consuming and requires special equipment, the solution can be made quickly and economically in every laboratory.

¹ This work was supported by a special research grant from the Ministére de L'Education, Québec, Canada, and was undertaken as a special project of the Council for Tobacco Research, U. S. A. and the Canadian Tobacco Industry.

Received 1/ 8/70. Accepted 3/18/70.