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Influence of Multiple Injections of Normal Syngeneic Cells on Tumor Induction in Mice

Sloan-Kettering Institute for Cancer Research, New York, New York 10021

Treatment of mice with suspensions of normal syngeneic liver cells twice a week for 25 weeks reduced the oncogenic response to a subsequent i.m. injection of methylcholanthrene. A similar course of injections with X-irradiated liver cells caused a somewhat greater decrease in tumor incidence. The mechanism of this interference with oncogenesis is unknown.

¹ Supported in part by Research Grant CA 08748 from the National Cancer Institute.

² Dr. Reiner died November 1, 1969. Requests for reprints should be addressed to Dr. Chester M. Southam.

Received 1/20/70. Accepted 4/ 7/70.