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The Effects of 2-Acetylaminofluorene and Nitrite on Free Radicals and Carcinogenesis in Rat Liver¹

Department of Botany [B. C., J. C. W., B. H. S.], The Center for the Biology of Natural Systems [B. C.], and Department of Surgery [J. L. T.], Washington University, St. Louis, Missouri 63130

The intensity of the abnormal electron spin resonance signal previously observed in the livers of rats which were fed various chemical carcinogens is found to depend on the intake of the carcinogen, protein, and nitrate or nitrite. Nitrite enhances the intensity of the abnormal electron spin resonance signal and inhibits the carcinogenicity of 2-acetyl-aminofluorene. The appearance of the signal-bearing complex and the possible mechanism of its anticarcinogenic activity are discussed.

¹ This investigation was supported by Research Grants 5 RO1 CA-03983 and 5 P10 ES-00139 from the USPHS, HEW.

Received 7/ 8/69. Accepted 4/ 8/70.

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