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Influence of Prednisolone on Moloney Leukemogenic Virus in BALB/c Mice¹

Laboratory of Viral Biology, National Cancer Institute, NIH, Bethesda, Maryland 20014 [H. T. A.], and Microbiological Associates, Inc., Walkersville, Maryland 21793 [L. S. R.]

Long-term administration of prednisolone to BALB/c mice alters the reactivity of their lymphoid tissue to the oncogenic effects of Moloney leukemia virus. Solid lymphosarcoma or granulocytic leukemia is produced in a significant number of the treated mice. The alteration in disease response may be attributed to a prednisolone-induced simulated thymectomy.

¹ Supported in part by the Special Virus-Cancer Program, National Cancer Institute, NIH, USPHS, Contract No. PH 43-67-697.

² Present address: Children's Hospital Medical Center, Department of Medicine, 300 Longwood Ave., Boston, Mass. 02115.

Received 12/30/69. Accepted 4/22/70.

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