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Effects of Dietary Fat and Dose Level of 7,12-Dimethylbenz()-anthracene on Mammary Tumor Incidence in Rats¹

Department of Biochemistry, University of Western Ontario,³ London 72, Ontario, Canada

Female Sprague-Dawley rats maintained on a semisynthetic diet containing 20% corn oil developed more mammary tumors after treatment with a single p.o. dose of 7,12-dimethylbenz()anthracene than rats treated similarly but fed a low-fat semisynthetic diet. The tumor yield varied with the dose of 7,12-dimethylbenz()anthracene, but the rats on high-fat diet developed more tumors at each of 3 dose levels tested. The type of diet fed after administration of 7,12-dimethylbenz()anthracene had a greater influence on mammary tumor incidence than did the type fed before the carcinogen was given, indicating that the effect is exerted mainly at the promotional stage of mammary carcinogenesis.

¹ Supported by the National Cancer Institute of Canada.

² Medical Research Associate of the Medical Research Council of Canada.

³ Part of this work was carried out in the Collip Medical Research Laboratory.

Received 2/ 2/70. Accepted 5/ 7/70.