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The Circulation of Malignant Lymphoid Cells in Thoracic Duct Lymph of Rats with Lymphosarcoma and Lymphatic Leukemia¹

Department of Surgery [B. K. S.] and Medicine, University of Manitoba, and Manitoba Cancer Treatment and Research Foundation [G. J. G.], Winnipeg, Canada

The circulation of lymphoid cells in thoracic duct lymph of rats with lymphosarcoma (LSA) and leukemia was investigated. Rats were inoculated with Murphy-Sturm lymphosarcoma either by the i.m. route, which yields a localized tumor-simulating LSA, or by the i.v. route, which results in lymphatic leukemia (LL). Thoracic duct fistulae were established in four groups of rats, including untreated normal rats, rats inoculated with normal lymphocytes, and rats inoculated with Murphy-Sturm lymphosarcoma to produce either LSA or LL. The percentage of large lymphocytes in thoracic duct lymph of rats with LSA and LL was higher than that of either control group and was greater in leukemic rats than in those with LSA. Chromosomal studies provided direct evidence for the circulation of malignant lymphoid cells to the thoracic duct of rats with either leukemia or LSA, but this phenomenon appeared to be quantitatively more significant in rats with LL.

¹ This study was supported by grants from the National Cancer Institute of Canada and the Medical Research Council of Canada.

² Clinical Research Associate, National Cancer Institute of Canada.

Received 2/ 4/70. Accepted 5/13/70.