This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lin, J.-Y. Articles by Tung, T.-C. Search for Related Content PubMed PubMed Citation Articles by Lin, J.-Y. Articles by Tung, T.-C.

Effect of Crystalline Abrin on the Biosynthesis of Protein, RNA, and DNA in Experimental Tumors¹

Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

Crystalline abrin isolated from Abrus precatorius L. has been shown to have a strong inhibitory effect on the protein biosynthesis of Ehrlich ascites tumor and Yoshida ascites hepatoma cells and a moderate inhibitory effect on the DNA biosynthesis of these neoplastic cells. It has no significant effects on the RNA biosynthesis and cellular respiration of these neoplastic cells at a much higher concentration of abrin than that required for curing the tumor. The inhibitory effect of abrin was not significantly changed by addition of glucose. By heating the solution of abrin at 100° for 30 min, the inhibitory effect of abrin was completely abolished.

¹ This investigation was supported in part by the National Council of Science, Republic of China, and by the China Medical Board, New York, N. Y. It was presented at the Sixth Congress of the Confederation of Medical Associations in Asia and Oceania, Taipei, Taiwan, November 1969.

Received 3/12/70. Accepted 5/28/70.