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Cellular Immunity to Rous Sarcoma in Tumor-bearing Chickens¹

Department of Medical Microbiology and Pathology, University of Lund, Lund, Sweden

Chickens carrying primary sarcomas induced by Schmidt-Ruppin Rous virus were studied for possible cellular immunity against the tumor-specific transplantation antigens of those tumors by use of the colony inhibition test. The thymus cells of 7 out of 8 tested chickens were found to reduce significantly the colony formation of Rous sarcoma cells while they had no similar effect on other types of tumors tested in paralle. It was further shown that thymus cells which had been frozen, stored in liquid nitrogen for 3 months, and subsequently thawed kept their specific colony-inhibiting activity. The implications of these findings are discussed.

¹ This work was supported by grants from The Swedish Cancer Society (Projects 116-K69-03Xa and 81-B69-92X) and from the Medical Faculty of the University of Lund.

Received 4/ 9/70. Accepted 5/28/70.