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Erythropoietic Effect of Plasma from Patients with Advanced Cancer¹

Department of Medicine, Long Island Jewish Medical Center-Queens Hospital Center, Jamaica, New York 11432

The erythropoietic effect of plasma from anemic and nonanemic patients with various cancers was determined by increase in percentage of incorporation of injected ⁵⁹Fe into circulating RBC's of protein-deprived CF₁ adult female mice in 48 hr. In 14 anemic patients with lymphoma or leukemia and in 12 anemic patients with solid tumors, the erythropoietic effect of plasma was significantly reduced compared to 12 normal plasmas but was increased compared to 0.9% NaCl solution controls (p < 0.001). In contrast, the erythropoietic effect of plasma in 8 nonanemic patients (4 lymphomas or leukemias and 4 solid tumors) was similar to normal controls but was significantly different from results in their anemic counterparts (p < 0.001).

¹ This work has been supported by Mildred Werner, League of Great Neck for Cancer Research, Greak Neck, New York.

² Physician-in-Charge of Oncology, to whom reprint requests should be sent at: Department of Medicine, Queens Hospital Center, 82-68 164th Street, Jamaica, N. Y. 11432.

³ Fellow in Oncology.

Received 1/28/71. Accepted 5/17/71.