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Effect of Dopamine and 6-Hydroxydopamine on Mouse Neuroblastoma Cells in Vitro¹

Department of Radiology, University of Colorado Medical Center, Denver, Colorado 80220

Dopamine and to a much greater extent, 6-hydroxydopamine reduced the growth of the mouse neuroblastoma cell population in vitro but did not induce morphological differentiation. The growth inhibition at a lower drug concentration was primarily due to inhibition of cell multiplication, which was reversible. L-Dopa, norepinephrine, epinephrine, 3,4-dihydroxyphenylacetic acid, or homovanillic acid at a similar concentration did not affect the growth of the neuroblastoma cell population in vitro. Dopamine and 6-hydroxydopamine have little or no effect on the growth of Chinese hamster ovary (CHO-K1) and baby hamster kidney (BHK-21) cell populations in vitro.

¹ This work was supported by USPHS Grant NS09230 from the National Institute of Neurological Disease and Stroke and by a grant from the Milheim Foundation for Cancer Research. Part of this work was presented at the Tenth Annual Meeting of the American Society for Cell Biology, San Diego, Calif., 1970.

Received 2/ 2/71. Accepted 5/21/71.

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