| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois 60439
The effects of dietary phenobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The simultaneous feeding of AAF and phenobarbital reduced the hepatocarcinogenic effects of AAF. In contrast, the sequential feeding of AAF and phenobarbital resulted in a significant increase in the incidence of hepatomas. No ill effects were observed in rats fed phenobarbital alone.
AAF and phenobarbital each stimulated the proliferation of hepatocytes, but, whereas the effect of AAF was maintained for the duration of exposure, the effect of phenobarbital was short lived. Phenobarbital fed simultaneously with AAF decreased the effect of AAF on liver cell proliferation.
1 This work was supported by the United States Atomic Energy Commission.
Received 3/11/71. Accepted 6/ 4/71.
This article has been cited by other articles:
|
|
 |
|
  J. Groos, P. Bannasch, M. Schwarz, and A. Kopp-Schneider Comparison of Mode of Action of Four Hepatocarcinogens: A Model-Based Approach Toxicol. Sci., October 1, 2007; 99(2): 446 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kim, K. Morimura, Y. Shah, Q. Yang, J. M. Ward, and F. J. Gonzalez Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice Carcinogenesis, May 1, 2007; 28(5): 940 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Singh, P. H. Driever, and J. W. Sander Cancer risk in people with epilepsy: the role of antiepileptic drugs Brain, January 1, 2005; 128(1): 7 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Conney Enzyme Induction and Dietary Chemicals as Approaches to Cancer Chemoprevention: The Seventh DeWitt S. Goodman Lecture Cancer Res., November 1, 2003; 63(21): 7005 - 7031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kinoshita, H. Wanibuchi, K. Morimura, M. Wei, J. Shen, S. Imaoka, Y. Funae, and S. Fukushima Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression Carcinogenesis, August 1, 2003; 24(8): 1389 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Ledda-Columbano, M. Pibiri, D. Concas, F. Molotzu, G. Simbula, C. Cossu, and A. Columbano Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand, TCPOBOP Carcinogenesis, June 1, 2003; 24(6): 1059 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ittrich, E. Deml, D. Oesterle, K. Kuttler, W. Mellert, S. Brendler-Schwaab, H. Enzmann, L. Schladt, P. Bannasch, T. Haertel, et al. Prevalidation of a Rat Liver Foci Bioassay (RLFB) Based on Results from 1600 Rats: A Study Report Toxicol Pathol, January 1, 2003; 31(1): 60 - 79. [Abstract] [PDF]
|
|
|
|
 |
|
 K. G. Calfee-Mason, B. T. Spear, and H. P. Glauert Vitamin E Inhibits Hepatic NF-{kappa}B Activation in Rats Administered the Hepatic Tumor Promoter, Phenobarbital J. Nutr., October 1, 2002; 132(10): 3178 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Komlosh, G. Volohonsky, N. Porat, C. Tuby, E. Bluvshtein, P. Steinberg, F. Oesch, and A. A. Stark {gamma}-Glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines Carcinogenesis, April 1, 2002; 23(4): 669 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kinoshita, H. Wanibuchi, S. Imaoka, M. Ogawa, C. Masuda, K. Morimura, Y. Funae, and S. Fukushima Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21WAF1/Cip1, cyclin D1 and Ogg1 Carcinogenesis, February 1, 2002; 23(2): 341 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Williams and M. J. Iatropoulos Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and Toxicity Toxicol Pathol, January 1, 2002; 30(1): 41 - 53. [Abstract] [PDF]
|
|
|
|
|
|
A. Komlosh, G. Volohonsky, N. Porat, C. Tuby, E. Bluvshtein, P. Steinberg, F. Oesch, and A. A. Stark {gamma}-Glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines Carcinogenesis, December 1, 2001; 22(12): 2009 - 2016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Kaufmann, C. I. Behe, V. M. Golubovskaya, L. L. Byrd, C. D. Albright, K. M. Borchet, S. C. Presnell, W. B. Coleman, J. W. Grisham, and G. J. Smith Aberrant cell cycle checkpoint function in transformed hepatocytes and WB-F344 hepatic epithelial stem-like cells Carcinogenesis, August 1, 2001; 22(8): 1257 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bitsch, N. Hadjiolov, P.-C. Klohn, O. Bergmann, I. Zwirner-Baier, and H.-G. Neumann Dose Response of Early Effects Related to Tumor Promotion of 2-Acetylaminofluorene Toxicol. Sci., May 1, 2000; 55(1): 44 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takaba, K. Saeki, K. Suzuki, H. Wanibuchi, and S. Fukushima Significant overexpression of metallothionein and cyclin D1 and apoptosis in the early process of rat urinary bladder carcinogenesis induced by treatment with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium L-ascorbate Carcinogenesis, April 1, 2000; 21(4): 691 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-H. Lee Review Article: Paradoxical Effects of Phenobarbital on Mouse Hepatocarcinogenesis Toxicol Pathol, March 1, 2000; 28(2): 215 - 225. [Abstract] [PDF]
|
|
|
|
|
|
N. Finnberg, U. Stenius, and J. Hogberg Xenobiotics Modulate the p53 Response to DNA Damage in Preneoplastic Enzyme-Altered Foci in Rat Liver; Effects of Diethylnitrosamine and Phenobarbital Toxicol. Sci., March 1, 2000; 54(1): 95 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sanders and S. S. Thorgeirsson Phenobarbital promotes liver growth in c-myc/TGF-{alpha} transgenic mice by inducing hypertrophy and inhibiting apoptosis Carcinogenesis, January 1, 1999; 20(1): 41 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Sagartz, S. W. Curtiss, R. T. Bunch, J. C. Davila, D. L. Morris, and C. L. Alden Phenobarbital Does Not Promote Hepatic Tumorigenesis in a Twenty-Six-Week Bioassay in p53 Heterozygous Mice Toxicol Pathol, July 1, 1998; 26(4): 492 - 500. [Abstract] [PDF]
|
|
|
|
|
|
S. Ito, M. Tsuda, A. Yoshitake, T. Yanai, and T. Masegi Effect of Phenobarbital on Hepatic Gap Junctional Intercellular Communication in Rats Toxicol Pathol, March 1, 1998; 26(2): 253 - 259. [Abstract] [PDF]
|
|
|
|
 |
|
 S. M. Cohen Cell Proliferation in the Evaluation of Carcinogenic Risk and the Inadequacies of the Initiation-Promotion Model International Journal of Toxicology, January 1, 1998; 17(3_suppl): 129 - 142. [PDF]
|
|
|
|
|
|
T. Shirai Review Article: A Medium-Term Rat Liver Bioassay as a Rapid In Vivo Test for Carcinogenic Potential: A Historical Review of Model Development and Summary of Results from 291 Tests Toxicol Pathol, September 1, 1997; 25(5): 453 - 460. [Abstract] [PDF]
|
|
|
|
|
|
R. M. McClain The Significance of Hepatic Microsomal Enzyme Induction and Altered Thyroid Function in Rats: Implications for Thyroid Gland Neoplasia Toxicol Pathol, February 1, 1989; 17(2): 294 - 306. [Abstract] [PDF]
|
|
|
|
 |
|
 A.E.M. McLean Is Enzyme Induction Good for You? A Problem of Epidemiology and Toxicology Human and Experimental Toxicology, September 1, 1988; 7(5): 419 - 422. [Abstract] [PDF]
|
|
|
|
|
|
D. Dixon, S.D. Sleight, S.D. Aust, and M.S. Rezabek Tumor-Promoting, Initiating, and Hepatotoxic Effects of 3,4,3',4'-Tetrabromobiphenyl (34-TBB) in Rats International Journal of Toxicology, September 1, 1988; 7(5): 687 - 697. [Abstract] [PDF]
|
|
|
|
|
|
M. I. R. Perera, J. M. Betschart, M. A. Virji, S. L. Katyal, and H. Shinozuka Free Radical Injury and Liver Tumor Promotion Toxicol Pathol, January 1, 1987; 15(1): 51 - 59. [Abstract] [PDF]
|
|
|
|
|
|
M. Tatematsu, H. Tsuda, T. Shirai, T. Masui, and N. Ito Placental Glutathione S-Transferase (GST-P) as a New Marker for Hepatocarcinogenesis: In Vivo Short-Term Screening for Hepatocarcinogens Toxicol Pathol, January 1, 1987; 15(1): 60 - 68. [Abstract] [PDF]
|
|
|
|
|
|
T. Kitagawa Promoting and Anticarcinogenic Effects of Phenobarbital and DDT in the Rat Hepatocarcinogenesis Toxicol Pathol, April 1, 1986; 14(3): 309 - 314. [Abstract] [PDF]
|
|
|
|
 |
|
 M. A. Pereira Mouse Liver Tumor Data: Assessment of Carcinogenic Activity Toxicology and Industrial Health, January 1, 1985; 1(4): 311 - 333. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Klaunig, P. J. Goldblatt, D. E. Hinton, M. M. Lipsky, and B. F. Trump Carcinogen Induced Unscheduled DNA Synthesis in Mouse Hepatocytes Toxicol Pathol, February 1, 1984; 12(2): 119 - 125. [Abstract] [PDF]
|
|
|
|
|
|
G. M. Williams Phenotypic Properties of Preneoplastic Rat Liver Lesions and Applications to Detection of Carcinogens and Tumor Promoters Toxicol Pathol, February 1, 1982; 10(2): 3 - 10. [Abstract] [PDF]
|
|
|
|
|
|
P. Bannasch, M. A. Moore, F. Klimek, and H. Zerban Biological markers of preneoplastic foci and neoplastic nodules in rodent liver Toxicol Pathol, February 1, 1982; 10(2): 19 - 34. [Abstract] [PDF]
|
|
|
|
|
|
N. Ito, H. Tsuda, R. Hasegawa, and K. Imaida Sequential observation of pathomorphologic alterations in preneoplastic lesions during the promoting stage of hepatocarcinogenesis and the development of short-term test system for hepatopromoters and hepatocarcinogens Toxicol Pathol, February 1, 1982; 10(2): 37 - 47. [Abstract] [PDF]
|
|
|
|
|
|
S. D. Vesselinovitch Liver Tumor Induction Toxicol Pathol, February 1, 1982; 10(2): 110 - 119. [Abstract] [PDF]
|
|
|
|
|
|
Liver Tumor Induction Toxicol Pathol, February 1, 1982; 10(2): 119 - 120. [PDF]
|
|
|
|
|
|
J. Schuppler, R. Schulte-Hermann, I. Timmermann-Trosiener, and P. Gunzel Proliferative liver lesions and sex steroids in rats Toxicol Pathol, February 1, 1982; 10(2): 132 - 143. [Abstract] [PDF]
|
|
|
|
|
|
Liver Lesions from Sex Steroids Toxicol Pathol, February 1, 1982; 10(2): 143 - 144. [PDF]
|
|
|
|
|
|
B. L. V. Duuren Cocarcinogens and Tumor Promoters and Their Environmental Importance International Journal of Toxicology, January 1, 1982; 1(1): 17 - 27. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Pereira Rat Liver Foci Bioassay International Journal of Toxicology, January 1, 1982; 1(1): 101 - 117. [Abstract] [PDF]
|
|
|
|
|
|
S. Goldfarb and T. D. Pugh The Origin and Significance of Hyperplastic Hepatocellular Islands and Nodules in Hepatic Carcinogenesis International Journal of Toxicology, January 1, 1982; 1(1): 119 - 144. [Abstract] [PDF]
|
|
|
|
|
|
News From the Society Toxicol Pathol, December 1, 1973; 1(4): 26 - 32. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
