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A Review of Isozymes in Cancer¹

Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida 32601

Several distinct isozymic systems which were observed to have alterations during differentiation from the normal to the neoplastic state have been reviewed. Most of these isozymes are key pathway or regulatory enzymes of intermediary metabolism. The isozymic systems which were reviewed include DNA polymerase, hexokinase-glucokinase, fructose 1,6-diphosphatase, aldolase, pyruvate kinase, lactate dehydrogenase, isocitrate dehydrogenase, malate dehydrogenase, glycerol phosphate dehydrogenase, glutaminase, aspartate aminotransferase, adenylate kinase, carbamylphosphate synthetase, and lactose synthetase. The basic isozymic system was outlined, and alterations which occurred in the neoplastic state were discussed in terms of the postulated role for that particular isozymic system in cellular metabolism.

¹ This work was supported by the Florida Division of the American Cancer Society (Grant F71UF-1).

Received 4/21/71. Accepted 6/15/71.

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