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Stimulation or Suppression of Metastases with Graded Doses of Tumor Cells¹

Harvard Medical School Department of Surgery at the Peter Bent Brigham Hospital [R. R. V., E. A. G., R. E. W.]; Peter Bent Brigham Hospital [H. G. S.] and Harvard Medical School [J. G.]; Boston, Massachusetts 02115

Varying doses of syngeneic fibrosarcoma cells, injected into the left limb at the time of amputation of the right tumor-bearing limb, either augmented or inhibited development of lung metastases in mice. Two different tumors were investigated, and with each 1 x 10⁴ live tumor cells provided complete protection from metastases. In both tumor lines, increasing the number of live tumor cells or using irradiated tumor cells at equivalent or greater dosage increased the incidence of metastases.

¹ These studies were supported in part by grants from the Atomic Energy Commission, USPHS, Avalon Foundation, and the Hartford Foundation.

² To whom requests for reprints should be addressed.

Received 4/20/71. Accepted 6/28/71.