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Comparison of Local Cellular Reaction to Tumor Grafts in Mice Treated with Some Plant Polysaccharides

National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, Japan

Local cellular reactions around s.c. grafts of Sarcoma 180 were examined in mice treated with several plant polysaccharides, some known to be antitumor active and others known to be inactive.

Extensive outpouring of lymphoid cells, mostly plasma cells and macrophages, in the immediate vicinity of the graft at an early period (1 week after implantation) and later invasion into the graft by connective tissue cells characterized the effect of polysaccharides which suppressed the tumor grafts, namely, wheat straw hemicellulose B, lichen polysaccharide GE-3, and lentinan. These characteristic cellular reactions were either absent or slight in untreated controls, negative controls treated with inactive polysaccharides (wheat straw hemicellulose A and sunflower stalk hemicellulose B), and autochthonous controls against which none of the polysaccharides showed any effect.

The findings with transplanted allogeneic tumors cannot be evaluated on an exact immunological basis, but they may be of interest in suggesting a possible role of the local lymphoid cell reaction in allogeneic tumor graft rejection.

Received 2/11/71. Accepted 6/11/71.