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Some Determinants of Camptothecin Responsiveness in Leukemia L1210 Cells¹

Department of Pharmacology and Toxicology and Division of Oncology, University of Rochester School of Medicine, Rochester, New York 14620

The antineoplastic alkaloid camptothecin inhibits nucleic acid synthesis in leukemia L1210 cells; this inhibition is initially reversible, but becomes irreversible when exposure to the drug is prolonged. A drug-resistant subline, L1210/CN, can overcome camptothecin-induced inhibition of nucleic acid biosynthesis before this becomes irreversible. Unlike actinomycin D-resistant cell lines, L1210/CN was not characterized by a drug permeability barrier nor by altered levels of cell surface glycoprotein.

¹ Supported by Grants CA-11198 and CA-11242 from NIH, a grant from the Monroe County Cancer and Leukemia Society, and institutional (General Research Support Grant) funds.

Received 5/ 3/71. Accepted 7/13/71.

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