This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Burki, H. R. Articles by Okita, G. T. Search for Related Content PubMed PubMed Citation Articles by Burki, H. R. Articles by Okita, G. T.

Effect of Mammary Tumor Virus Infection on in Vivo Oxidation of Glucose-1-¹⁴C and Glucose-6-¹⁴C in C3H Mice¹

Northwestern University Medical School, Department of Pharmacology, Chicago, Illinois 60611

The in vivo oxidation of glucose-1-¹⁴C and glucose-6-¹⁴C was measured in C3H and C3Hf female virgin mice of different ages. C3H virgins after the age of 4 to 6 months exhibited a faster rate of glucose-6-¹⁴C, but not glucose-1-¹⁴C, oxidation than C3Hf factor-free controls. No difference was observed between the two strains of mice with respect to the blood glucose level, but C3H virgins attained lower body weights than C3Hf controls. These results suggested that the mammary tumor virus, transmitted in the milk of C3H mice, may induce in the host alterations in regulatory systems controlling growth and glucose metabolism. The presence of a transplanted mammary tumor, which had arisen spontaneously in a C3H exbreeder female, had no effect on body weight and glucose-6-¹⁴C oxidation of C3H virgins but caused an elevation in glucose-6-¹⁴C oxidation and a reduction in body weight in C3Hf virgin hosts. Thus, the level of glucose-6-¹⁴C oxidation and the body weight of C3Hf recipients of mammary tumor transplants were comparable to that of C3H virgins with or without mammary tumor transplants.

¹ This investigation was supported by USPHS Research Grant CA 07930 from the National Cancer Institute and NIH Training Grant GM-00162 from the National Institute of General Medical Sciences.

² Present address: Research Institute, Dr. A. Wander Ltd., P. O. Box 2747, 3001 Bern, Switzerland.

Received 1/26/71. Accepted 8/ 3/71.