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Immunofluorescent Studies of Lymph Nodes and Spleens of Leukotic Cattle for Cells Producing IgM and IgG

Kimron Veterinary Institute, Post Office Box 12, Bet Dagan, Israel

Lymph nodes and spleens of 31 leukotic cattle were subjected to immunofluorescent testing to ascertain whether they contained IgM- and IgG-producing cells. The tests indicated that the comparatively marked reduction of IgM in the serum of leukotic cattle was due to a decline in the production of IgM in the spleen and lymph nodes. In the lymph nodes concerned, no IgM-producing cells were found, while 3 to 5 IgG-producing cells per field were present. It appears, therefore, that the damage to the lymph system of leukotic cattle is selective and primarily affects the IgM-producing cells. The findings also indicate that the damage to the IgM-producing cells seems to occur before the morphological changes are visible.

Received 3/15/71. Accepted 7/16/71.