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Alterations in Morphology and Growth Pattern in a Transplantable Leukemia of Rats

Research Laboratories, Food and Drug Directorate, Department of National Health and Welfare, Ottawa, K1A OL2, Ontario, Canada

A transplantable Wistar rat leukemia of a mononuclear type is described. Its growth patterns and morphological characteristics during 17 serial passages are considered. The leukemic cell was characterized by lymphoid or monocytoid morphologically recognizable features, phagocytic properties, nuclear karyorrhexis, and an abortive attempt towards myeloid transformation. Severe anemia with bone marrow erythroid hypoplasia was often associated with the disease. In several instances during serial passage, the neoplasm assumed a solid sarcomatous pattern, with or without accompanying blood changes. The morphological peculiarities of this leukemia are compared with those of other mononuclear leukemias.

Received 4/29/71. Accepted 7/28/71.