This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shearer, R. W. Articles by Smuckler, E. A. Search for Related Content PubMed PubMed Citation Articles by Shearer, R. W. Articles by Smuckler, E. A.

A Search for Gene Derepression in RNA of Primary Rat Hepatomas¹

Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98105

The technique of RNA/DNA hybridization in the presence of competing RNA was used to look for genetic derepression in primary rat hepatomas. No qualitative difference was demonstrable between the RNA's of different hepatomas and normal liver, although quantitative differences related to frequencies of various cell types do exist. The results preclude any gross activation of gene families during tumorigenesis but do not assay for inactivation. The data suggest that an alteration in transport of RNA out of the cell nucleus may be important.

¹ Supported by USPHS Grants CA-42423 and AM-08686, American Cancer Society Grant E-480A, and an institutional grant from the American Cancer Society.

² Present address: Pacific Northwest Research Foundation, 1102 Columbia St., Seattle, Wash. 98104.

Received 5/17/71. Accepted 8/12/71.

This article has been cited by other articles:

				D Gillespie and R. Gallo RNA processing and RNA tumor virus origin and evolution Science, May 23, 1975; 188(4190): 802 - 811. [Abstract] [PDF]