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Prolonged Survival of Male-to-Female Skin Isografts and of Allografts from Normal Mice following Treatment of Recipient or Graft with Sera from Tumor-bearing Mice¹

Department of Immunology, Hebrew University, Hadassah Medical School, Jerusalem, Israel

Prolonged survival of normal skin allografts from donors with neoplastic disease has been reported previously in laboratory animals and humans. The experiments in mice reported here were conducted to determine whether this phenomenon can be extended to skin from foreign, normal donors by means of serum from isogenic animals with actively growing neoplasms.

Male C57BL mice were given s.c. implants of a syngeneic, male, solid lymphosarcoma. Macroscopically normal skin grafts taken from the tumor-bearing mice several weeks later survived longer in normal female C57BL recipients than did skin isografts from normal male donors. There was a very marked and significant prolongation of the survival of male skin isografts from normal donors when these were preincubated with serum from tumor-carrying C57BL males prior to implantation into the isogenic females. Similarly, injection of such serum into the female recipients of skin isografts from normal males several hours before grafting elicited marked and significant prolongation of the life of the grafts. Normal male serum failed to exert a significant effect, both when used for incubation of the grafts and when injected.

Similar results were obtained in an allograft system, in which normal skin was transplanted from normal C57BL males to normal BALB/c males and either the graft or the recipient animal was pretreated with serum from C57BL males carrying the isogenic lymphosarcoma.

¹ This work was supported by grants from the Leukemia Research Foundation, Inc.; Concern Foundation; Welfund, Inc.; and the Samuel Lautenberg Fellowship.

Received 8/10/70. Accepted 9/25/70.