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The Synergism between Radiation and Estrogen in the Production of Mammary Cancer in the Rat

Alton Ochsner Medical Foundation [A. S.] and The Ochsner Clinic, New Orleans, Louisiana 70121 [A. s., W. S. M.]

A x C rats, in which continous administration of diethylstilbestrol produces a high incidence of mammary carcinoma as opposed to their essentially zero spontaneous incidence, were given radiation of one mammary chain while they were under the systemic influence of diethylstilbestrol. The animals irradiated without the diethylstilbestrol, with the same dose and at the same time, developed fewer mammary carcinomas after a much longer latent period (minimum, 75 weeks), but those animals irradiated while under the influence of the estrogen had many more mammary carcinomas (the first at 18 weeks) than those given the diethylstilbestrol alone. This is interpreted as substantial synergism between the two modalities in mammary carcinogenesis.

¹ To whom requests for reprints should be addressed, at Alton Ochsner Medical Foundation, 1520 Jefferson Highway, New Orleans, La. 70121.

² Present address: Department of Radiology, Louisiana State University School of Medicine, New Orleans, La. 70112.

Received 8/ 4/69. Accepted 10/ 6/70.

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