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Ultrastructural Alterations within Hyperplastic Liver Nodules Induced by Ethionine¹

Divisions of Experimental Pathology, Section of Electron Microscopy [L. P. M., M. P.], and Microbiology [M. S.], William H. Singer Memorial Research Institute of the Allegheny General Hospital, Pittsburgh 15212, and Department of Pathology [S. M. E., E. F.], University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213

The ultrastructure of ethionine-induced hyperplastic liver nodules was compared to the adjacent nonnodular liver in the same rat and also to hyperplastic liver nodules induced by 2-fluorenylacetamide. Several reproducible cytostructural alterations were noted in ethionine-induced hyperplastic liver nodules of fasted animals but not in adjacent nonnodular liver. This set of alterations was quite similar to those noted in the hyperplastic liver nodules induced by 2-fluorenylacetamide. These observations suggest the hyperplastic liver nodules induced by different carcinogens have similar characteristics and represent a new cell population distinct and intermediate between adjacent nonnodular liver and hepatocellular carcinoma.

¹ Supported in part by grants from the American Cancer Society, Inc., and the Beaver County Cancer Society and by USPHS Research Grants CA 06074 and CA 10667 from the National Cancer Institute, Grant AM 05644 from the National Institute of Arthritis and Metabolic Diseases, and Grants GM 135 (a training grant) and GM 10269 (a research grant) from the National Institute of General Medical Sciences. This is Paper 4 of the series, "The Cellular Analysis of Liver Carcinogenesis."

² Recipient of a Career Development Research Award (KO-3-CA-15-245) from the National Cancer Institute.

Received 7/28/70. Accepted 10/13/70.