This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Clapp, N. K. Articles by Otten, J. A. Search for Related Content PubMed PubMed Citation Articles by Clapp, N. K. Articles by Otten, J. A.

Differences in Tumor Types and Organ Susceptibility in BALB/c and RF Mice following Dimethylnitrosamine and Diethylnitrosamine¹

Carcinogenesis Program, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

Total doses of 300 mg/kg of dimethylnitrosamine (DMN) and 515 and 1010 mg/kg of diethylnitrosamine (DEN) were given to adult BALB/c mice in their drinking water. The oncogenic results for this strain were compared with previously reported data on a noninbred subline of RF/Un mice handled under similar conditions. DEN induced forestomach and esophageal squamous cell carcinomas in both strains but induced liver hemangiosarcomas in BALB/c mice and liver hepatomas in RF mice. In addition, DEN induced a high incidence of lung adenomas in the RF but was only slightly effective (3%) in BALB/c mice. In both strains, DMN induced lung adenomas and liver hemangiosarcomas. The liver sensitivity of both strains to DEN, in developing different tumor cell types between strains, suggests that different liver cells may metabolize DEN in the two strains and offers an excellent tool for metabolic studies. These carcinogens induced high incidences of tumors in the low-tumor-incidence BALB/c strain, with the exception of DEN, which had no oncogenic effect on the lung. Tissue sensitivity does not appear to relate directly to the spontaneous tumor incidence of the strain. No leukemogenic effect was observed following either DMN or DEN in either strain.

¹ Research supported jointly by the National Cancer Institute and by the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation.

Received 6/23/70. Accepted 10/15/70.