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Nucleic Acid Metabolism of an Estrogen-dependent Carcinoma of the Adrenal Cortex of the Rat¹

Cancer Research Centre and Department of Biochemistry, University of British Columbia, Vancouver, B. C., Canada

The incorporation of radioactive precursors into RNA and DNA by an estrogen-dependent adrenocortical tumor of rats decreased following removal of the exogenous supply of estrogen. Reapplication of estrogen by implantation of an estrone pellet or by injection of estradiol-17ß increased the labeling of RNA in a regressing tumor within 1 to 4 hours, but a similar effect on DNA was not consistently observed until later. When the regressing tumor was compared with the growing one, nuclear RNA was labeled more rapidly in the former whereas less radioactive cytoplasmic RNA was found, which suggests that estrogen may be involved in transport of RNA from nucleus to cytoplasm. The cytoplasmic RNA content of regressing tumors was only 70 to 75% of the concentration in growing tumors, as shown by quantitative measurements.

¹ This work was supported by the National Cancer Institute of Canada and the Medical Research Council of Canada.

² Recipient of a Fellowship from the National Cancer Institute of Canada.

Received 4/16/70. Accepted 11/16/70.