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Influence of Liver Regeneration on the Loss of Fluorenylacetamide Derivative Bound to Liver DNA¹

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

N-Hydroxy-2-fluorenylacetamide-9-¹⁴C was injected i.p. into rats, and the degree of labeling of purified liver DNA was determined 16 hr later. The loss of the label from the DNA was followed subsequently over a period of 11 days. It was found that, within this period, 75% of the label was removed from the DNA. Active DNA replication, induced by partial hepatectomy, did not appear to influence the rate of removal of the 2-fluorenylacetamide derivative from the DNA in any major way.

¹ Supported by research grants from the American Cancer Society and from National Institutes of Health [CA-060274 and CA-10667 from the National Cancer Institute, GM-135 (a training grant), and GM-10269 from the National Institutes of General Medical Sciences].

² Present address: Department of Pharmacology, University of Montreal, Montreal, Quebec, Canada.

³ Recipient of a Career Development Research Award from the National Cancer Institute (K03CA-15245).

⁴ Present address: Fels Research Institute, Temple University School of Medicine, Philadelphia, Pa. 19140.

Received 6/26/70. Accepted 11/16/70.