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Lack of N-Hydroxy-2-acetylaminofluorene Sulfotransferase Activity in the Mammary Gland and Zymbal's Gland of the Rat¹

Veterans Administration Hospital and Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38104

The O-sulfonate of N-hydroxy-2-acetylaminofluorene was not formed in vitro in the mammary gland or in the sebaceous gland of the external auditory canal (Zymbal's gland), tissues of the rat that are highly susceptible to carcinogenesis by 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene. Consequently, the O-sulfonate of N-hydroxy-2-acetylaminofluorene, reported to be an ultimate reactive metabolite of these carcinogens in male rat liver, does not appear to be involved in the mechanism of carcinogenesis in all tissues of the rat in which tumors are induced by these compounds.

¹ Supported by Part I Designated Research Funds of the U.S. Veterans Administration and by USPHS Grant CA-05490 from the National Cancer Institute.

Received 11/ 3/70. Accepted 12/ 3/70.