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The Relation of Thymidine Labeling Index in Human Tumors in Vitro to the Effectiveness of 5-Fluorouracil Chemotherapy¹

Division of Clinical Oncology and Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53706

The percentage of tumor cells that incorporated tritiated thymidine during a 24-hr in vitro incubation was determined in 565 human tumors. The percentage of cells labeled with thymidine varied greatly among tumors arising from the same tissue of origin. The mean percentage of cells labeled was 2.9. No relationship could be demonstrated between the percentage of tumor cells labeled with thymidine and the response to monthly courses of 5-fluorouracil in 148 patients.

¹ Supported by Grants CA-05953 and CA-06749 from the National Cancer Institute, USPHS.

Received 8/24/70. Accepted 12/14/70.