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Absence of an Effect of Partial Hepatectomy on Aflatoxin B₁ Carcinogenesis¹

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

The effect of partial hepatectomy on aflatoxin B₁ (AFB₁) carcinogenesis in rat liver has been examined in Fischer and Sprague-Dawley rats. Partial hepatectomy performed before or after the administration of AFB₁ had no effect on the development of hepatocarcinoma, compared to either sham hepatectomy or no operation. When AFB₁ administration was begun 6 hr after either hepatectomy or sham operation, the incidence of carcinoma was less than that found when AFB₁ treatment was begun between 24 hr and 6 days after surgery. Sprague-Dawley rats were less sensitive than Fischer rats to the carcinogenic effects of AFB₁.

¹ This work was supported in part by USPHS Grant RO1-AM-CA-11158 from the National Institute of Arthritis and Metabolic Diseases and USPHS Grant RO1-CA-08870 from the National Cancer Institute.

Received 10/16/70. Accepted 1/20/71.