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Gastric Tumors and Lung Lesions in the Rat following the Intragastric or Intraperitoneal Administration of N-(ß-Chloroethyl)-N-nitrosourethan

M. R. C. Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey [R. S.], and Department of Biophysics, Institute of Cancer Research, Belmont, Surrey [J. P. M. B.], England

N-(ß-Chloroethyl)-N-nitrosourethan given intragastrically to rats in one or two doses not exceeding 15 mg/kg body weight induced tumors among 12 rats that survived longer than 1 year, one of the esophagus, one of the forestomach, and three of the glandular stomach.

When a single dose of N-(ß-chloroethyl)-N-nitrosourethan was given i.p. (about 5 mg/kg body weight), there were many early deaths from exudative and proliferative alveolar changes in the lungs, and none of the rats survived longer than 6 months.

The possible reasons for the high efficacy of N-(ß-chloroethyl)-N-nitrosourethan as a carcinogen are discussed.

Received 5/26/70. Accepted 1/22/71.