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The Effects of ß-2'-Deoxythioguanosine on Survival and Progression in Mammalian Cells¹

Section of Cellular Studies, Department of Physics, University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025

Synchronized Chinese hamster ovary cells were most sensitive to ß-2'-deoxythioguanosine (ß-TGdR) in early and mid S phase. However, little effect on DNA synthesis was observed. One possible mechanism that could account for cell lethality in S-phase cells would be errors made in DNA replication subsequent to incorporation of ß-TGdR into DNA. Mitotic cells were totally unaffected and G₁ cells were only slightly sensitive to ß-TGdR. Treatment with ß-TGdR did not cause progression or division delay, even when cells were treated in early and mid S phase when survival was reduced to 11%.

¹ This work was supported in part by NIH Grants CA 05099 and CA 04484.

Received 12/ 3/70. Accepted 1/22/71.