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Effect of Ozone on Benzpyrene Hydroxylase Activity in the Syrian Golden Hamster

Environmental Protection Agency, Air Pollution Control Office, Division of Health Effects Research, Cincinnati, Ohio 45237

Exposure of Syrian golden hamsters to increasing concentrations of ozone decreases benzpyrene hydroxylase activity in the lungs as much as 70%, while the benzpyrene hydroxylase activity in the liver remains unchanged. The degree of inhibition is the same for both artificially induced high enzyme levels and normal, relatively low enzyme levels. Lung weight comparisons are used to show that dilution of the enzyme, secondary to edema formation, plays only a small part in the reductions in enzyme activity. Ozone may act as a cocarcinogen with inhaled benz(a)pyrene by delaying the enzymatic transformation of the hydrocarbon.

Received 10/29/70. Accepted 1/27/71.

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