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Light Microscopic Observations of Morris Hepatomas¹

Department of Pathology, University of Chicago, Illinois 60637 [Z. H., Y. M., A. S.]; Department of Biochemistry, Cancer Research Unit, Howard University, Washington, D. C. 20001 [H. P. M.]; and Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141 [D. R. M.]

Light microscopic examination of transplantable hepatomas with a wide spectrum of growth rates and analysis of structure based on the criteria of Elias reveal rough correlations between structure and growth rate. Fast-growing hepatomas are formed by multicellular laminae, have small cells and abundant mitoses, and lack glycogen and follicles. Hepatomas with intermediate growth rates contain tubular and follicular structures. Slowly growing hepatomas contain single-cell laminae. However exceptions are many, particularly among the slowly growing hepatomas.

¹ Supported by USPHS Grant CA-05310 from the National Cancer Institute, NIH.

² Recipient of a Research Career Development Grant. To whom requests for reprints should be sent, at: Box 414, University of Chicago, 950 East 59th Street, Chicago, Ill. 60637.

Received 10/ 9/70. Accepted 1/28/71.