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Transfer RNA Methylase Activity in Normal Rat Liver and Some Morris Hepatomas

Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203 [B. S., S. M. W.], and Department of Biochemistry, Howard University, School of Medicine, Washington, D. C. 20001 [H. P. M.]

Increased tRNA methylase activity was demonstrated for six transplantable Morris hepatomas with different growth rates in comparison to normal rat liver. Although there was increased tRNA methylase corresponding to the growth rates of the hepatomas, it was not possible to establish a linear relationship. Similar tRNA methylation patterns were produced by enzyme extracts prepared from rat liver, two different well-differentiated hepatomas, and two different poorly differentiated hepatomas.

¹ Supported in part by USPHS Grant CA 10729.

Received 10/29/70. Accepted 1/29/71.