This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wolberg, W. H. Search for Related Content PubMed PubMed Citation Articles by Wolberg, W. H.

Inhibition of Migration of Human Autogenous and Allogeneic Leukocytes by Extracts of Patients' Cancers¹

Division of Clinical Oncology and Department of Surgery, University of Wisconsin Medical Center, Madison, Wisconsin 53706

Studies have shown the importance of the delayed hypersensitivity reaction in the body's defense against cancer. Production of migration-inhibitory factors is characteristic of the delayed hypersensitivity reaction. Delayed hypersensitivity to chemically induced tumors has been demonstrated in animals by inhibition of macrophage migration.

In our study, preparations from 19 of 21 human tumors inhibited leukocyte migration. Some preparations were cytotoxic to both autogenous and allogeneic migrating leukocytes. Growth of heterologous hepatoma cells in tissue culture was not inhibited by some preparations that inhibited leukocyte migration. It appears that both cytotoxic and migration-inhibiting substances can be liberated by tumor-leukocyte interaction. Such factors may prevent interaction between cancer cells and human tumors and thereby inhibit the cellular immune response in cancer patients.

¹ This work was supported by USPHS Grant CA 05953.

Received 11/24/70. Accepted 2/ 5/71.