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Regression of Prolactin-dependent Rat Mammary Carcinoma in Response to Antihormone Treatment¹

Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

Rabbit antibodies to purified rat prolactin were produced and injected into female Sprague-Dawley rats bearing 7,12-dimethylbenzanthracene-induced, hormone-dependent mammary adenocarcinomas. Antihormone therapy caused a significantly increased incidence of tumor regression and a significantly decreased growth of tumors in these rats compared with controls receiving normal rabbit serum. These results provide further evidence to support the conclusion that 7,12-dimethylbenzanthracene-induced rat mammary cancer is prolactin dependent.

¹ Presented at the Annual Meeting of the American Association for Cancer Research, Inc., April 1970.

² This work was done in partial fulfillment of the requirements for the degree of Doctor of Medicine at Case Western Reserve University School of Medicine.

³ Supported by USPHS Grant CA-05197-10 and American Cancer Society, Inc., Grant T46J.

Received 10/29/70. Accepted 1/28/71.