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Inhibition of Growth of Ehrlich Ascites Tumors in ICR/Ha Swiss Mice by Isocyanates¹

Department of Chemistry, State University College, Fredonia, New York 14063

The growth of Ehrlich tumors has been inhibited by 17 isocyanates injected i.p. in peanut oil. Eight isocyanates increase mean survival times. Two isocyanates, active in peanut oil, are inactive when dispersed in 0.85% NaCl solutions. The isocyanates hence become a new class of cancer inhibitors.

¹ Supported in part by grants from the Fredonia College Foundation of State University of New York, Inc., and the Joint Awards Council/University Awards Committee of the State University of New York/Research Foundation. Presented in part before the Division of Biological Chemistry, 158th National Meeting of the American Chemical Society, New York, N. Y., September 12, 1969.

Received 1/23/70. Accepted 3/ 2/71.