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Promotion of Aflatoxin-induced Hepatoma Growth in Trout by Methyl Malvalate and Sterculate¹

Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331

Young rainbow trout fed 20 ppb aflatoxin B₁ for 1, 5, 10, 20, and 30 days developed 12-month hepatoma incidences of 3, 12, 10, 40, and 36%, respectively. Fish fed the same level of aflatoxin B₁ in diets containing 100 ppm methyl sterculate for the same time periods developed 0, 17, 27, 74, and 85% incidences of hepatoma.

Fish that had received 20 ppb aflatoxin B₁ for 30 days were given either 0, 20, 50, or 100 ppm methyl sterculate for 9 months. Liver tumor incidences were 37, 65, 80, and 95%, respectively. The average volumes of tumor tissue per liver were 1, 52, 532, and 3450 cu mm for the corresponding diets. Methyl malvalate showed little tumor growth-promoting activity when fed in an identical manner at 50 ppm.

¹ This work was supported in part by USPHS Grant ES-00263 and ES-00256. Presented in part at the Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N. J., April 1970. Paper No. 2941, Oregon Agricultural Experiment Station.

Received 9/14/70. Accepted 3/ 5/71.

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