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On the Association between Photodynamic and Enzyme-inducing Activities in Polycyclic Compounds¹

Laboratories of Environmental Toxicology and Carcinogenesis, Children's Cancer Research Foundation, Inc., and Department of Pathology, Harvard Medical School, Boston, Massachusetts [S. S. E.], and Institut Lannelongue de Recherche sur la Cancerogenese Chimique et Hormonale, 27, Rue Diderot, 92-Vanves, France [N. P. B-H., D.-P. H.]

The photodynamic activities of 240 polycyclic compounds, determined with Paramecium caudatum, were compared with their in vivo induction of zoxazolamine hydroxylase activity in rats. A highly significant association was demonstrated between photodynamic and enzyme-inducing activities. Compounds with high photodynamic activity had 10 times greater odds of inducing hydroxylase activity than compounds with low photodynamic activity. Properties associated with enzyme induction appear necessary but not sufficient for high photodynamic activity.

¹ This investigation was supported by NIH Grants C-6516 and FR-05526, National Air Pollution Control Administration Contract CPA 70-17, and the Regie Nationale des Tabacs (SEITA), France.

Received 9/22/70. Accepted 4/ 1/71.