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In Vivo Human-Hamster Somatic Cell Fusion Indicated by Glucose 6-Phosphate Dehydrogenase and Lactate Dehydrogenase Profiles¹

Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 [D. M. G., R. A. P.], and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 [D. M. G., R. D. B., R. A. P.]

Transplantation of a human lymphoma to the cheek pouches of unconditioned, adult golden hamsters resulted in permanently transplantable tumors which grow progressively and kill their hosts. This tumor system, GW-478, has a hamster-specific lactate dehydrogenase isoenzyme mobility pattern and both human and hamster glucose 6-phosphate dehydrogenase enzyme profiles when propagated in the hamster or in vitro, thus suggesting that GW-478 is a human-hamster hybrid.

¹ Supported by Grant 640 from The Council for Tobacco Research-U. S. A., by USPHS Grant CA-12374-02 from the National Cancer Institute, and by Grant IN-581 from the American Cancer Society to the University of Pittsburgh.

² Present address: Department of Pathology, Temple University School of Medicine, Philadelphia, Pa. 19140.

Received 9/ 4/70. Accepted 4/ 1/71.

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