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The Effects of Bleomycin on Survival and Cell Progression in Chinese Hamster Cells in Vitro¹

Section of Cellular Studies, Department of Physics, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025

Bleomycin is most effective at killing Chinese hamster ovary cells in mitosis and in G₂ phase. Mitosis is the most sensitive phase. In order of increasing resistance were cells treated in G₂ phase, early S phase, late S phase, and G₁ phase. Interference with cell progression occurred only in cell populations treated with Bleomycin in G₂ phase.

¹ This work was supported in part by NIH Grants CA 05099 and CA 04484.

Received 12/21/70. Accepted 4/21/71.

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