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Tissue Isoantigens A, B, and H in Carcinoma of the Pancreas¹

Department of Pathology, The Chicago Medical School/University of Health Sciences, and Department of Experimental Pathology, Mount Sinai Hospital Medical Center, Chicago, Illinois 60608

The isoantigens A, B, and H of the red blood cells of Groups A, B, and O are also present in the normal epithelial cells of the exocrine glands of the pancreas. They are absent in Langerhans's islands and in the connective tissue. They are readily demonstrable with the Coombs' mixed-cell agglutination reaction. We studied the effect of cancerous transformation on the three antigens in primary and metastatic carcinomas of the pancreas. They could not be demonstrated in over 80% of the cases. With rare exceptions, the loss of demonstrable antigen paralleled morphological anaplasia. This technique promises to be useful in the early diagnosis and prognosis of carcinoma of the pancreas.

¹ Supported in part by USPHS Grant CA 10261.

Received 3/ 8/71. Accepted 4/27/71.

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