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Hyperbasophilic Foci as Sites of Neoplastic Transformation in Hepatic Parenchyma¹

Laboratories de Recherche, Institut du Cancer de Montréal, Hôpital Notre-Dame and Département d'Anatomie, Université de Montréal, Montréal,^,4 Canada

The occurrence of hyperbasophilic foci and tumors has been investigated in livers of rats fed (a) hepatocarcinogens, (b) hepatotoxic but noncarcinogenic agents, and (c) basal control diets. Hyperbasophilic foci were found to develop exclusively in livers of animals fed hepatocarcinogens, thus suggesting a close correlation between the occurrence of such areas and tumor formation.

The properties of the hyperbasophilic foci have also been examined in sections submitted to mild RNase treatment, which selectively extracts the RNA responsible for hyperbasophilia. Some foci differed from the surrounding tissue only by their increased basophilia and showed no other apparent change. Most foci showed one or several additional changes but could still be distinguished from the tumors which, in addition, showed a displacement of the surrounding parenchyma. The hyperbasophilic foci thus differ from both the regenerating parenchyma from which they arise and from the tumors. They appear to be a transitional tissue and probably represent the sites of neoplastic transformation.

¹ This work was supported by grants from the National Cancer Institute of Canada.

² Research Associate of the National Cancer Institute of Canada.

³ Research Fellow of the National Cancer Institute of Canada.

⁴ Mailing address: Institut du Cancer de Montréal, Hôpital Notre-Dame, 1560 est rue Sherbrooke, Montréal, Canada.

Received 12/21/70. Accepted 5/11/71.

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