Cancer Research
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[Cancer Research 31, 1313-1315, September 1, 1971]
© 1971 American Association for Cancer Research
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Adenosine 3',5'-Cyclic Monophosphate and Contact Inhibition

Margaret L. Heidrick1 and Wayne L. Ryan

College of Medicine, University of Nebraska, Omaha, Nebraska 68105

Adenosine 3',5'-cyclic monophosphate (cAMP) and cyclic nucleotide phosphodiesterase were assayed in strain L cells from the 2nd to the 6th day of incubation. cAMP increases markedly when the culture reaches confluency on the 4th day of incubation. The phosphodiesterase increased in a similar but less dramatic manner. cAMP and cyclic nucleotide phosphodiesterase were measured in two nontumorigenic cell lines and five tumorigenic cell lines at confluency. The level of cAMP is higher in the nontumorigenic cultures and is related to the population-doubling time of the cells. It is proposed that contact inhibition of growth may be mediated by activation of adenyl cyclase in the cell membranes with subsequent rise in cellular cAMP.

1 Predoctoral USPHS trainee (2T1HD18010).

Received 3/24/71. Accepted 5/20/71.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1971 by the American Association for Cancer Research.