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Expression of Various Tumor-specific Antigens in Polyoma Virus-induced Tumors

Cellular and Tumor Immunology Section, Laboratory of Cell Biology, National Cancer Institute; Bionetics Research Laboratories, Inc.; and Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases Bethesda, Maryland 20014

The quantitative expression of tumor-specific transplantation antigen, tumor-specific cell surface antigen, and T-antigen in polyoma virus-induced tumors was studied. A mouse polyoma virus-transformed cell line (4198) and its variant line (4198V) were both shown to possess polyoma tumor-specific transplantation antigen, but the variant line was more immunosensitive. The 4198V cells had 8.8 times more tumor-specific cell surface antigen as detected by the isotopic antiglobulin technique. More polyoma T-antigen was also found in the 4198V cells. A similar correlation of tumor antigen expression has been observed with SV40-induced tumors.

¹ Supported in part by USPHS Contract 70-2207 to Bionetics Research Laboratories, Inc., Bethesda, Md.

Received 7/23/71. Accepted 8/30/71.