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Antitumor Activity of Glyceryl Ethers

Laboratory of Microbiology, Department of Agricultural Chemistry, the University of Tokyo, Bunkyo-ku. Tokyo, Japan

Antitumor activity of fatty alcohols and a-glyceryl ethers of fatty alcohols was examined with Ehrlich carcinoma in mice. Significant antitumor activity was exerted against Ehrlich ascites carcinoma by i.p. administration of capryl, lauryl, and myristyl a-glyceryl ethers. Capryl and lauryl glyceryl ethers suppressed the growth of solid tumor when administered through various routes. Administration s.c. was the most effective.

¹ Present address: Research Laboratories, Chugai Pharmaceutical Co., Ltd., Toshima-ku, Tokyo, Japan.

Received 12/30/69. Accepted 9/14/71.