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Response of DNA Thymine Synthesis in Human Tumor and Normal Tissue to 5-Fluorouracil¹

Division of Clinical Oncology and Department of Surgery, University of Wisconsin Medical Center, Madison, Wisconsin 53706

Human tumor tissue and the normal tissue from which it arose similarly incorporated DNA thymine precursors. The effect of 5-fluorouracil on alternative pathways of DNA thymine synthesis was similar in both tumor and normal tissue. Differential drug sensitivity was not demonstrated.

¹ This work was supported by USPHS Grant CA 05953.

Received 5/21/71. Accepted 9/17/71.