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Effects of Mithramycin on Bone Resorption in Vitro¹

Department of Medicine A, Roswell Park Memorial Institute, Buffalo, New York 14203

Embryonic rat bones labeled with ⁴⁵CaCl₂ are stimulated in vitro by parathyroid extract to release ⁴⁵Ca. Mithramycin prevents this active release over a broad range of dose levels that are nonlethal to the bones, as evidenced by their subsequent responsiveness to additional parathyroid extract. The similarity of dose levels used to concentrations (based on calculated dilution) after clinical administration supports the interpretation that clinical effects of mithramycin in hypercalcemic patients are due to a direct effect on bone.

¹ This investigation was supported by USPHS Grant Ca-5834 from the National Cancer Institute.

Received 7/21/71. Accepted 9/15/71.

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